A big factor can be what the actual "listing" says because that is considered the definitive description of the features that are of historical interest. I know of an old school building where an owner was allowed to clad the bell tower in uPVC because the listing didn't mention that it was timber clad, but the totally unremarkable "open fire place" couldn't be bricked up or otherwise enclosed without going through full planning & heritage committee because it was explicitly mentioned in the listing!
The best way of dealing with a listed building is to sell it. Not sure which I was glad to see the back of, my ex wife or the listed farmhouse I sold to pay her off. Both cost me a fortune over the years and gave me lots of grief.