Sepsis !!!

Pilatus

Member
We heard today that some one we know is lucky to be alive after Sepsis infection while on holiday in the US.
It’s obviously an extremely dangerous infection ( or whatever its term).
Is it very common in the 21st century?
 

som farmer

Member
Livestock Farmer
Location
somerset
2 elderly relatives, in a home contracted it, both recovered, after time in hospital.

seems to be on the rise, local girl contracted it, after giving birth, amputated some limbs, but she didn't make it.

A/B resistance, will see it increase.
 

Wesley

Member
Far more common than a lot of people realise.
I went indoors early one afternoon not feeling too great. Told my other half I just wanted to go to bed. Had no energy & felt pretty rough. Luckily she was far more concerned than I was as I normally just get on with it. Persuaded me to go see someone. Ended up on a drip with antibiotics. Sounded like if I’d gone to bed & I’d been left there too long there was a high chance I wouldn’t have woken up.
 

Wesley

Member
As above its more common than most know , i had never even heard about it …
I was in my 30’s, fit & very healthy. I went to bed the previous night perfectly fine, woke up the next morning with a really big, swollen knee. Never thought once the infection that caused it could’ve ended up being fatal. I’d never heard about sepsis either.
I take things like it a bit more seriously now. I’ll admit it scares me a bit that I was going to ignore it. I only went to get checked out to keep the peace.
 
There is a lot of confusion about sepsis. Virtually all NHS organisations live in a perpetual state of paranoia about sepsis.

It isn't actually as common as the public might be convinced it is. Let me explain.

Sepsis is not simply an infection. Sepsis is caused by an over-exaggerated response to infection. Thus, giving someone antibiotics is not the direct 'cure' for sepsis. The antibiotics target the pathogen you are infected with, which means the immune system can calm down and not wipe your organs (and hence the rest of you) out. Sepsis is thus actually caused by your own body- that paranoid partially sighted old geezer that sits on that rocking chair all day complaining about the world, warning people not to walk on his lawn whilst cradling his most beloved shotgun is sitting there inside your body and is what makes up your immune system.

This level of paranoia, as I said, has somehow manifested itself into healthcare organisations. It is thus now basically nationwide policy that anyone turning up with deranged vital signs and/or confusion gets dosed with (often but not always, IV) antibiotics. As we know, dosing up lots of people with antibiotics is a recipe for antibiotic resistance but here we are following a policy that does exactly that.

Yes, a portion of the people who turn up in hospital with funny vital signs are likely septic, they may even have a full blown blood-borne bacteraemia for which antibiotics certainly are needed. But the science tells us that this cannot be the case for all of them. We know that sepsis can be triggered by other pathogens such as viruses, fungi or even simple parasites that regular antibiotics might not even have any effect on. But because blood test results take time to come back, it is safer to pre-emptively load the patient up with antibiotics. Other medicines can be used later as needed.

I'll go into the (very long) list of effects that paranoid old man and his shotgun can have tomorrow. That there is not a 'cure' for sepsis in the 21st century is a multifaceted question as the immune system is a complicated beast that we don't fully understand and don't have full control of, at least not yet.
 
Last edited:

Wesley

Member
This level of paranoia, as I said, has somehow manifested itself into healthcare organisations. It is thus now basically nationwide policy that anyone turning up with deranged vital signs and/or confusion gets dosed with (often but not always, IV) antibiotics.

But because blood test results take time to come back, it is safer to pre-emptively load the patient up with antibiotics.
My experience of Royal Devon & Exeter hospital is I had to wait for blood test results before I was treated. Even though I had very low blood pressure, high heart rate (it was still around 150+ after I’d hardly moved from a hospital bed or wheelchair for god knows how many hours) & other usual symptoms.
However I was told after by a nurse friend that I should’ve been treated as you said. She was really pushing me to make a complaint & extremely unhappy after she asked my symptoms.
 
My experience of Royal Devon & Exeter hospital is I had to wait for blood test results before I was treated. Even though I had very low blood pressure, high heart rate (it was still around 150+ after I’d hardly moved from a hospital bed or wheelchair for god knows how many hours) & other usual symptoms.
However I was told after by a nurse friend that I should’ve been treated as you said. She was really pushing me to make a complaint & extremely unhappy after she asked my symptoms.

I wouldn't be fair to comment on any place I have no direct experience of or have previously worked in; the health service isn't an homogenous entity and there is sometimes great variety in procedures and local guidelines or how various organisations operate their departments.

People with obviously deranged vital signs (and/or neurological signs like confusion that is unusual for them) should be brought to the attention of a senior doctor without delay (this may well have occurred in your case, who is to say). It is then up to them to tick the box and begin treatment (usually empirical antibiotics etc) or provide a reasoning as to why they believe the patient does not have a bacterial infection with associated sepsis. This kind of decision making is for very senior doctors only as they are basically signing their name onto that decision and it takes years of training and experience to be able to make that call as it may involve a life or limb. Very low blood pressure in an otherwise normally fit and well adult is a very common indication that sepsis is occurring and I will explain why tomorrow.
 

toquark

Member
Used to be called blood poisoning or something, but as I understand it it’s not one single disease, it could be any one of a number of bacterial infections you could catch often just doing fairly innocuous tasks (hedge cutting as mentioned), or getting a scratch climbing a barb wire fence as happened to my friend, who very nearly succumbed to it a few years ago.
 

Hill Ground

Member
Livestock Farmer
Location
Bucks
There is a lot of confusion about sepsis. Virtually all NHS organisations live in a perpetual state of paranoia about sepsis.

It isn't actually as common as the public might be convinced it is. Let me explain.

Sepsis is not simply an infection. Sepsis is caused by an over-exaggerated response to infection. Thus, giving someone antibiotics is not the direct 'cure' for sepsis. The antibiotics target the pathogen you are infected with, which means the immune system can calm down and not wipe your organs (and hence the rest of you) out. Sepsis is thus actually caused by your own body- that paranoid partially sighted old geezer that sits on that rocking chair all day complaining about the world, warning people not to walk on his lawn whilst cradling his most beloved shotgun is sitting there inside your body and is what makes up your immune system.

This level of paranoia, as I said, has somehow manifested itself into healthcare organisations. It is thus now basically nationwide policy that anyone turning up with deranged vital signs and/or confusion gets dosed with (often but not always, IV) antibiotics. As we know, dosing up lots of people with antibiotics is a recipe for antibiotic resistance but here we are following a policy that does exactly that.

Yes, a portion of the people who turn up in hospital with funny vital signs are likely septic, they may even have a full blown blood-borne bacteraemia for which antibiotics certainly are needed. But the science tells us that this cannot be the case for all of them. We know that sepsis can be triggered by other pathogens such as viruses, fungi or even simple parasites that regular antibiotics might not even have any effect on. But because blood test results take time to come back, it is safer to pre-emptively load the patient up with antibiotics. Other medicines can be used later as needed.

I'll go into the (very long) list of effects that paranoid old man and his shotgun can have tomorrow. That there is not a 'cure' for sepsis in the 21st century is a multifaceted question as the immune system is a complicated beast that we don't fully understand and don't have full control of, at least not yet.
You say it's an immune reaction, and getting more common.

Could it be something similar to auto immune diseases and allergic reactions seemingly getting more common? Both of those are immune system attacking the body too arnt they?
 

Lincs Lass

Member
Location
north lincs
Friends niece,43 got a tiny piece of glass in her big toe about a year ago , she collapsed 3 days later , into hospital,sepsis had set in .
To save her ,they amputated all her toes on that foot .
She's lucky in a sense, she could have lost her leg or died
 
You say it's an immune reaction, and getting more common.

Could it be something similar to auto immune diseases and allergic reactions seemingly getting more common? Both of those are immune system attacking the body too arnt they?

I can't say it is getting more common. I can't say auto-immune conditions are getting more common either, because in truth I don't know the statistics.

The truth is that we have beaten a lot of formerly very nasty diseases. Modern vaccines (an average UK child has about £300 worth of vaccines before they are 18) has sorted a lot of the childhood ones.
 
I imagine it’s just more heard of than it used to be rather than happening any more. Maybe people use its name more rather than x died from an infection etc.

There have been some high profile failures of people's care in the past where sepsis resulted in some very bad outcomes. Now the entire health service is fixated on sepsis and has all kinds of protocols in place in an attempt to mitigate it. It is no more or less common than it ever was, it's just the campaign and constant attention it gets.

To be fair, the public should probably have better awareness of it because it is the delay in them approaching hospital care that is possibly one of the biggest drivers of outcome. Mind, I'm the same as many people in that I wouldn't go to secondary (or primary) care services, I'd sooner take pills and sleep it off. I recall having a temperature of 40 degrees at one point in the past and decided to just have a lie down and sleep all night. Woke up drenched in sweat but right as rain. The trick of it is spotting it in other people where it's not so straight forward.
 

Flossie

Member
Livestock Farmer
Location
Lancs

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