Ivermectin , covid cure

ollie989898 said:

Don't talk trash. The government said no such thing. The data regarding the pharmacokinetics of the fudging vaccine was in the public domain in December 2020.

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So your saying he made that up and he definitely didn't get that information from any government information or politician?

tepapa said:

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So your saying he made that up and he definitely didn't get that information from any government information or politician?

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1. He made a video ages earlier telling us that vaccines put into muscles end up in the blood.

2. In DECEMBER 2020 (I.e. when the first authorisation of use was granted) Pfizer told the MHRA (who published it on their own website) the pharmacokinetics of this stuff. Not that it was any great surprise because a small monkey, if pressed on it's basic knowledge of immunology, could have told you where the vaccine would likely have ended up because mRNA vaccines are not new.

Your guy lied, pure and simple. You can't accept it but that is your own failing, not mine. The fact you are even trying to argue this is hilarious. We were not told anything of the sort- he is making a total fabrication and that is bullsh(t of the highest order.

ollie989898 said:

1. He made a video ages earlier telling us that vaccines put into muscles end up in the blood.

2. In DECEMBER 2020 (I.e. when the first authorisation of use was granted) Pfizer told the MHRA (who published it on their own website) the pharmacokinetics of this stuff. Not that it was any great surprise because a small monkey, if pressed on it's basic knowledge of immunology, could have told you where the vaccine would likely have ended up because mRNA vaccines are not new.

Your guy lied, pure and simple. You can't accept it but that is your own failing, not mine. The fact you are even trying to argue this is hilarious. We were not told anything of the sort- he is making a total fabrication and that is bullsh(t of the highest order.

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For starters, he's not my guy, I just don't buy into the hate campaign against him. I purely come on this thread to read the bickering and sometimes a little fishing but I try and avoid that.
I'm just trying to understand your side of the arguement. So your saying he made all that up about it staying in the arm and he didn't get that information from any government source at the time. Not even from a politician who may have no scientific knowledge about the subject but who was still prepared to stand up and state things as facts?

From what I gather this mRNA vaccine is nothing like any other type of vaccine that precedes it. They even changed the definition of vaccine to accommodate it. Even if it is from old research it was definitely new technology not used in humans before.

ollie989898 said:

Don't talk trash. The government said no such thing. The data regarding the pharmacokinetics of the fudging vaccine was in the public domain in December 2020.

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So it was.

Go straight to section 3, where the pharmacokinetics are shown. Or rather, it shows thatthe testing and results were mostly bypassed thanks to a WHO loophole:



Pharmacokinetic studies have not been conducted with COVID-19 mRNA Vaccine BNT162b2 and are generally not considered necessary to support the development and licensure of vaccine products for infectious diseases (WHO, 2005; WHO, 2014).

The ADME profile of COVID-19 mRNA Vaccine BNT162b2 included evaluation of the PKand metabolism of the two novel lipid excipients (ALC-0315 and ALC-0159) in the LNPand potential in vivo biodistribution using luciferase expression as a surrogate reporter.

Absorption​

No absorption studies were conducted for COVID-19 mRNA Vaccine BNT162b2 since the route of administration is intramuscular (IM).

The “Single dose pharmacokinetics study of ALC-0315 and ALC-0159 following intravenous bolus injection of a nanoparticle formulation in rats” was conducted to assess the PK and metabolism of the two novel lipid excipients (ALC-0315 and ALC-0159). This study used LNPs containing surrogate luciferase RNA, with the lipid composition being identical to BNT162b2, to investigate the in vivo disposition of ALC-0159 and ALC-0315.

Concentrations of ALC-0159 dropped approximately 8000- and >250-fold in plasma and liver, respectively, during this 2-week study. For ALC-0315, the elimination of the molecule from plasma and liver was slower, but concentrations fell approximately 7000- and 4-fold in two weeks for plasma and liver, respectively. Overall, the apparent terminal t½ in plasma and liver were similar in both tissues and were 2-3 and 6-8 days for ALC-0159 and ALC0315, respectively. The apparent terminal t½ in plasma likely represents the re-distribution of the respective lipids from the tissues into which they have distributed as the LNP, back to plasma where they are eliminated.

Distribution​

Study R-20-0072 evaluated the in vivo potential biodistribution of COVID-19 mRNAVaccine BNT162b2 in mice using luciferase expression as a surrogate reporter. Protein expression was demonstrated at the site of injection and to a lesser extent, and more transiently, in the liver after mice received an IM injection of RNA encoding luciferase in an LNP formulation like BNT162b2. Luciferase expression was identified at the injection site at 6 hours after injection and diminished to near baseline levels by day 9. Expression in the liver was also present at 6 hours after injection and was not detected by 48 hours after injection. Information regarding the potential distribution of the test articles to sites other than the injection site following IM administration has been provided and is under review as part of the ongoing rolling assessment.

Metabolism​

The in vitro metabolism of ALC-0315 and ALC-0159 was evaluated in blood, liver microsomes, S9 fractions, and hepatocytes from mice, rats, monkeys, and humans. The in vivo metabolism was examined in rat plasma, urine, faeces, and liver samples from the PK study. Metabolism of ALC-0315 and ALC-0159 appears to occur slowly in vitro and in vivo. ALC-0315 and ALC-0159 are metabolised by hydrolytic metabolism of the ester and amide functionalities, respectively, and this hydrolytic metabolism is observed across the species evaluated.

Excretion​

No excretion studies have been conducted with COVID-19 mRNA Vaccine BNT162b2. In the PK study, it appears that 50% of ALC-0159 was eliminated unchanged in faeces. Metabolism played a role in the elimination of ALC-0315, as little to no unchanged material was detected in either urine or faeces. Investigations of urine, faeces and plasma from the rat PK study identified a series of ester cleavage products of ALC-0315. The manufacturer has proposed that this likely represents the primary clearance mechanism acting on this molecule, although no quantitative data is available to confirm this hypothesis. In vitro, ALC-0159 was metabolised slowly by hydrolytic metabolism of the amide functionality.

Pharmacokinetic drug interactions​

No PK drug interaction studies have been conducted with COVID-19 mRNA Vaccine BNT162b2. This is acceptable and in line with relevant guidelines (WHO 2005; WHO2014).



Now who is lying?
Had I have known all this, I might have thought twice about taking the vaccine!

More importantly, Dr. John Campbell, didn’t deliberately lie. He just updated his views.
Just the same as the Government have updated the above report on 21st March this year.

tepapa said:

For starters, he's not my guy, I just don't buy into the hate campaign against him. I purely come on this thread to read the bickering and sometimes a little fishing but I try and avoid that.
I'm just trying to understand your side of the arguement. So your saying he made all that up about it staying in the arm and he didn't get that information from any government source at the time. Not even from a politician who may have no scientific knowledge about the subject but who was still prepared to stand up and state things as facts?

From what I gather this mRNA vaccine is nothing like any other type of vaccine that precedes it. They even changed the definition of vaccine to accommodate it. Even if it is from old research it was definitely new technology not used in humans before.

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You're talking bilge, frankly.

These vaccines are not new technology. I believe this has already been discussed at length, should you require clarification on this, I suggest you use google because I'm frankly wasting my time repeating background knowledge you should already know before engaging in this thread.

He lied, pure and simple. That he either A forgot the fudging information he himself gave in an earlier video (unless you are saying it's not the same guy???) or B was completely misinformed about how vaccines work to begin with is hilarious given that you lot believe he is the patron saint of realtruth(TM). And now you are woefully trying to cover for him. It's pathetic frankly. I told you guys a dozen times the guy was an unreliable source of information but no you'd sooner believe in the youtube when the fudging information has been in the public domain from year dot. Him getting excited in the vaccine appearing in breast milk was also hilarious given that research on mRNA vaccines done years prior already demonstrated this and again, people with a cursory amount of immunology knowledge would know about this. But no, apparently his PhD landed in a bowel of cornflakes because he didn't know this and relied on the government telling him (they did no such thing- more lies) about it's pharmacokinetics? You're a lark.

The guy is either one of the most scientifically illiterate people with a youtube account or he just can't lie in bed straight at night. It's possibly both given the bulltrap he tried to peddle at the outset with his vaccine aspiration guidance which was quickly shot down in flames online also and demonstrably hopelessly out of date.

Maybe you guys should have stuck to the Rogan podcasts after all. At least he makes no secret he doesn't have a scoobies about anything.

Is there a disease known as sh!t-stirring?
If so, can it be cured by a Doctor?
Or does it need curing by well trained Nursing?

ollie989898 said:

These vaccines are not new technology

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You're talking bilge, frankly

Since this isn't new technology, could you please give an example of one other vaccine used in humans that used this mRNA technology prior to the COVID vaccine.

tepapa said:

You're talking bilge, frankly

Since this isn't new technology, could you please give an example of one other vaccine used in humans that used this mRNA technology prior to the COVID vaccine.

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Stop wasting my time, frankly. How in the heck are you trying to comment on something you don't know anything about?

ollie989898 said:

Stop wasting my time, frankly. How in the heck are you trying to comment on something you don't know anything about?

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By the sounds of it I know just as much as you.

Shall I put my question on the list of questions you will not answer?

tepapa said:

By the sounds of it I know just as much as you.

Shall I put my question on the list of questions you will not answer?

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You should listen to more Joe Rogan podcasts chum, it's where I get all my information.

Come on back when you have a question worth answering, won't you.

ollie989898 said:

Stop wasting my time, frankly. How in the heck are you trying to comment on something you don't know anything about?

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tepapa said:

You're talking bilge, frankly

Since this isn't new technology, could you please give an example of one other vaccine used in humans that used this mRNA technology prior to the COVID vaccine.

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She tried to come up with one before and failed, so won't try again.

For those wishing to learn more outside of the relevant Joe Rogan podcast, please read this paper, published in 2012, in which the authors discuss mRNA vaccine technology and many of the details and difficulties involved. It has an extensive references list also.

Conclusion: mRNA vaccine technology is not new. It is not unheard of. It is not something mystical or poorly understood. It was technology that had been sat on the shelf for years, unused, because of earlier problems with efficacy.

ollie989898 said:

For those wishing to learn more outside of the relevant Joe Rogan podcast, please read this paper, published in 2012, in which the authors discuss mRNA vaccine technology and many of the details and difficulties involved. It has an extensive references list also.

Conclusion: mRNA vaccine technology is not new. It is not unheard of. It is not something mystical or poorly understood. It was technology that had been sat on the shelf for years, unused, because of earlier problems with efficacy.

Developing mRNA-vaccine technologies

mRNA vaccines combine desirable immunological properties with an outstanding safety profile and the unmet flexibility of genetic vaccines. Based on in situ protein expression, mRNA vaccines are capable of inducing a balanced immune response comprising ...

www.ncbi.nlm.nih.gov

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What is new is it being used in a vaccine.
That is what the argument is about.

ollie989898 said:

For those wishing to learn more outside of the relevant Joe Rogan podcast, please read this paper, published in 2012, in which the authors discuss mRNA vaccine technology and many of the details and difficulties involved. It has an extensive references list also.

Conclusion: mRNA vaccine technology is not new. It is not unheard of. It is not something mystical or poorly understood. It was technology that had been sat on the shelf for years, unused, because of earlier problems with efficacy.

Developing mRNA-vaccine technologies

mRNA vaccines combine desirable immunological properties with an outstanding safety profile and the unmet flexibility of genetic vaccines. Based on in situ protein expression, mRNA vaccines are capable of inducing a balanced immune response comprising ...

www.ncbi.nlm.nih.gov

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Who TF is this Joe Rogan pal of yours you keep going on about?

Is he a spoof medic too?

Two Tone said:

Who TF is this Joe Rogan pal of yours you keep going on about?

Is he a spoof medic too?

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She's obsessed with people i never listen to.
Joe rogan, russel brand etc
Plus goes on about conspiracy theories all the time

Canada Farmer said:

Are you as delusional as our PM? Genuine question.

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I don't know your PM.


Canadian uptake of autumn boosters is pretty good, isn't it ~

Cowabunga said:

None, not one of the staff at my large local primary care practice has had a single covid vaccine dose, ever, I happen to know from full time employees there who are under pressure not to answer that question when asked. But I’ve known several since school days and we were basically brought up together. Nevertheless I’ve had three or four doses, can’t remember exactly. Only last Autumn’s dose have I missed.

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You said you have had your course of vaccination, fair enough ~ so if you are keeping yourself clear of places with high viral load, masking when necessary, you will be avoiding SARS-CoV-2. I wasn't in the age group offered an autumn booster, so I didn't miss it deliberately. If healthcare staff aren't up to date (all frontline medical staff were eligible for the autumn jab), then they'd better be masking and working in rooms with HEPA filterers.

This is how the autumn jab roll out looks like from England ~

tepapa said:

By the sounds of it I know just as much as you.

Shall I put my question on the list of questions you will not answer?

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You’ll be lucky, that scroll was filled long ago

primmiemoo said:

You said you have had your course of vaccination, fair enough ~ so if you are keeping yourself clear of places with high viral load, masking when necessary, you will be avoiding SARS-CoV-2. I wasn't in the age group offered an autumn booster, so I didn't miss it deliberately. If healthcare staff aren't up to date (all frontline medical staff were eligible for the autumn jab), then they'd better be masking and working in rooms with HEPA filterers.

This is how the autumn jab roll out looks like from England ~

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There's no need to go round avoiding it.
It's a cold
Even if you succeed , depriving your immune system of foes is harmful to your health.
Doing it on a societal level is also harmful

primmiemoo said:

You said you have had your course of vaccination, fair enough ~ so if you are keeping yourself clear of places with high viral load, masking when necessary, you will be avoiding SARS-CoV-2. I wasn't in the age group offered an autumn booster, so I didn't miss it deliberately. If healthcare staff aren't up to date (all frontline medical staff were eligible for the autumn jab), then they'd better be masking and working in rooms with HEPA filterers.

This is how the autumn jab roll out looks like from England ~

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I'm afraid you might be wasting your time with this. Actual reality has a bitter taste to some of these folks and they often avoid ever having to be confronted with it.

I'm rather losing count but how many times do they expect me to basically write the exact same things? Then they complain I don't ever answer their questions without stopping to think how completely banal most of them are. The defence of their messiah I find extremely amusing. Almost as satisfying mind as the deafening silence from other quarters. They didn't have any real response to the first time I posted it, either.