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<blockquote data-quote="ollie989898" data-source="post: 7189995" data-attributes="member: 54866"><p>Some evidence does suggest that higher doses of a vaccine are more effective than a standard comparative dose. That being said, this study is only talking about influenza and in a very specific population. When discussing a much larger effort with an emphasis on overall public health, there is clearly a cost-benefit discussion to be had.</p><p></p><p>[URL unfurl="true"]https://academic.oup.com/jid/article/217/11/1718/4858294[/URL]</p><p></p><p>There is a similar argument presently on-going about whether UK women should be given a 1, 2 or 3 doses of the HPV vaccine (HPV being thought to cause 80% of all cervical cancers so well worth pursuing). The 3 dose program I understand gives near lifetime protection from the virus but it is argued that a single dose is pretty effective on it's own.</p><p></p><p>[URL unfurl="true"]https://www.bmj.com/content/350/bmj.g7584[/URL]</p><p></p><p>[URL unfurl="true"]https://www.sciencedirect.com/science/article/pii/S0264410X19316597[/URL]</p><p></p><p></p><p>In any event as you describe the action of vaccines is wholly different to that of pesticides.</p></blockquote><p></p>
[QUOTE="ollie989898, post: 7189995, member: 54866"] Some evidence does suggest that higher doses of a vaccine are more effective than a standard comparative dose. That being said, this study is only talking about influenza and in a very specific population. When discussing a much larger effort with an emphasis on overall public health, there is clearly a cost-benefit discussion to be had. [URL unfurl="true"]https://academic.oup.com/jid/article/217/11/1718/4858294[/URL] There is a similar argument presently on-going about whether UK women should be given a 1, 2 or 3 doses of the HPV vaccine (HPV being thought to cause 80% of all cervical cancers so well worth pursuing). The 3 dose program I understand gives near lifetime protection from the virus but it is argued that a single dose is pretty effective on it's own. [URL unfurl="true"]https://www.bmj.com/content/350/bmj.g7584[/URL] [URL unfurl="true"]https://www.sciencedirect.com/science/article/pii/S0264410X19316597[/URL] In any event as you describe the action of vaccines is wholly different to that of pesticides. [/QUOTE]
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