The "man made" world as you put it is the natural world as we are part of nature and everything we do is in our nature to do, its no lesser a part of nature for man to fly to the moon than it is for a bear to sh1t in the woods.Combining the natural world with the manmade is really about the only way it seems a person can make it in agriculture. an example would be a farmer who only feeds his cattle bought grain vs a farmer who only feeds his cattle grass off of leased land.
We set what we do apart from the rest of nature at our own peril, we were created naturally and can be destroyed in the same way and the great scheme of things wouldn't bat and eyelid