Is now a good time to get it ?

Goweresque

Member
Location
North Wilts
Not really, latest research suggest the antibodies only last a few months. You'd lose the immunity around autumn, just as the winter wave kicks in...............ideally you'd get it late autumn, so you'd be OK when it all kicks off again over the winter. That's if you survive the first case of course........ :D
 

bobk

Member
Location
stafford
Not really, latest research suggest the antibodies only last a few months. You'd lose the immunity around autumn, just as the winter wave kicks in...............ideally you'd get it late autumn, so you'd be OK when it all kicks off again over the winter. That's if you survive the first case of course........ :D
It's all about T cells apparently , you can't store immunity
 
Not really, latest research suggest the antibodies only last a few months. You'd lose the immunity around autumn, just as the winter wave kicks in...............ideally you'd get it late autumn, so you'd be OK when it all kicks off again over the winter. That's if you survive the first case of course........ :D

The antibodies are not produced constantly nor do they circulate forever. If they did, this would be problematic since a huge range of immunoglobulins are produced and a lot of them are highly specific to the pathogen in question. For example, the last cold you had, the antibodies you produced in response to that don't 'fit' the flu virus you had last year; both of these viruses have different shaped antigens and will not fit just any random antibody. Also the blood is a pretty busy place as it is without having several thousand types of antibody floating around in it 24/7 just in case you get last year's flu virus or something. You would expend a lot of energy and effort producing antibodies of all kinds for absolutely no benefit.

Instead, there are cells that 'remember' previous encounters with earlier pathogens and produce the required antibodies when or if they are encountered again.

The importance of the 90 day antibody theory is that if we are testing people now, given that we are many months since the initial infections probably happened, how many people who test negative when tested by immunoassay, are already 'resistant'??
 

bobk

Member
Location
stafford
The antibodies are not produced constantly nor do they circulate forever. If they did, this would be problematic since a huge range of immunoglobulins are produced and a lot of them are highly specific to the pathogen in question. For example, the last cold you had, the antibodies you produced in response to that don't 'fit' the flu virus you had last year; both of these viruses have different shaped antigens and will not fit just any random antibody. Also the blood is a pretty busy place as it is without having several thousand types of antibody floating around in it 24/7 just in case you get last year's flu virus or something. You would expend a lot of energy and effort producing antibodies of all kinds for absolutely no benefit.

Instead, there are cells that 'remember' previous encounters with earlier pathogens and produce the required antibodies when or if they are encountered again.

The importance of the 90 day antibody theory is that if we are testing people now, given that we are many months since the initial infections probably happened, how many people who test negative when tested by immunoassay, are already 'resistant'??
You explained it perfectly .
 

Exfarmer

Member
Location
Bury St Edmunds
Not really, latest research suggest the antibodies only last a few months. You'd lose the immunity around autumn, just as the winter wave kicks in...............ideally you'd get it late autumn, so you'd be OK when it all kicks off again over the winter. That's if you survive the first case of course........ :D
There is absolutely no evidence antibodies only last a few months. This is a totally new disease and little solid research Has been done. Even less ith patients who are genuinely been known to have, actually had Covid.
article on BBC look east tonight about Covid long term issues interviewed a sufferer who apparently had no evidence at all that she had ever had Covid, but she is suffering long term:cautious::cautious::cautious:
 

Exfarmer

Member
Location
Bury St Edmunds

bobk

Member
Location
stafford
Also Spanish research found exactly the same:

That's not even the same scenario , we expect better from you
 

Goweresque

Member
Location
North Wilts
The antibodies are not produced constantly nor do they circulate forever. If they did, this would be problematic since a huge range of immunoglobulins are produced and a lot of them are highly specific to the pathogen in question. For example, the last cold you had, the antibodies you produced in response to that don't 'fit' the flu virus you had last year; both of these viruses have different shaped antigens and will not fit just any random antibody. Also the blood is a pretty busy place as it is without having several thousand types of antibody floating around in it 24/7 just in case you get last year's flu virus or something. You would expend a lot of energy and effort producing antibodies of all kinds for absolutely no benefit.

Instead, there are cells that 'remember' previous encounters with earlier pathogens and produce the required antibodies when or if they are encountered again.

The importance of the 90 day antibody theory is that if we are testing people now, given that we are many months since the initial infections probably happened, how many people who test negative when tested by immunoassay, are already 'resistant'??

Thats not correct. Antibody half life differs from disease to disease. For tetanus its about 11 years, 50 years for chickenpox, for measles its 200 years. I myself had a blood test late last year that revealed I'd had Epstein Barr virus (aka glandular fever) at some point in my life, the doctor said there was no way of knowing when, as the antibodies stay in the blood for your entire life once you've had it.



For the common cold and the flu the half life of the antibodies is very short, weeks or months. Hence why we get reinfected with them constantly. Covid is a coronavirus which is the common cold family, and it seems the antibodies fade within months, like for colds. Thus we will all be capable of catching it repeatedly over our lives, unless a vaccine that can stimulate a far longer antibody half life can be found, which seems unlikely given actually having the virus is going to stimulate the immune system far more than a mild form in a vaccine.
 

Ley253

Member
Location
Bath
One thing that seems to being kept quiet, is that while discovered infections are rising, fatalities are still dropping, and numbers requiring hospital treatment like wise.Another odd fact(unless you want to keep the numbers up) is that once you have had covid, its the only thing that will appear on your death cert, even if your run down by a car years later. North Wales man had it, recovered, then some months later heart failed, death cert said covid!
 

Exfarmer

Member
Location
Bury St Edmunds
The common cold is a rhinovirus of which their are thousands so we regularly get infected by a different variant.
one Coronavirus does cause common cold symptoms and is regularly seen among young children, but very rarely in older, suggesting, their is a very good chance that an infection of Covid 19 will not re occur. Some scientists believe, and I would emphasise a very small number, that a recent infection of a childhood coronavirus causing common cold symptoms may in fact give medium term term resistance to Covid 19, but at the moment there is zero proof
 

caveman

Member
Location
East Sussex.
One thing that seems to being kept quiet, is that while discovered infections are rising, fatalities are still dropping, and numbers requiring hospital treatment like wise.Another odd fact(unless you want to keep the numbers up) is that once you have had covid, its the only thing that will appear on your death cert, even if your run down by a car years later. North Wales man had it, recovered, then some months later heart failed, death cert said covid!
Good chance there are many long lasting effects on the person after "getting it" making other conditions more dangerous to life.
 
Thats not correct. Antibody half life differs from disease to disease. For tetanus its about 11 years, 50 years for chickenpox, for measles its 200 years. I myself had a blood test late last year that revealed I'd had Epstein Barr virus (aka glandular fever) at some point in my life, the doctor said there was no way of knowing when, as the antibodies stay in the blood for your entire life once you've had it.



For the common cold and the flu the half life of the antibodies is very short, weeks or months. Hence why we get reinfected with them constantly. Covid is a coronavirus which is the common cold family, and it seems the antibodies fade within months, like for colds. Thus we will all be capable of catching it repeatedly over our lives, unless a vaccine that can stimulate a far longer antibody half life can be found, which seems unlikely given actually having the virus is going to stimulate the immune system far more than a mild form in a vaccine.

They all disappear in time, yes. I don't know about the half life of particular antibodies I'm afraid. I would suspect that if not contacted for long periods of time the immunity begins to fade, this is one reason why the NHS does not opt for wide spread chickenpox vaccination, to ensure adults are being infected with the virus repeatedly throughout their lives.

The problem you will have with colds and flu is that there are dozens of different strains so there may be very little immunity to the latest one doing the rounds. Viruses mutate very readily over time and amongst different populations.

As I said earlier, the body simply won't be able to sustain mass-producing these proteins at the maximum rate forever and there is plenty of other things being carried around in the blood before jamming it with 3 million different times of antibody. The memory B cells, however, seem able to produce the correct antibody for many years.

There are (were) elderly survivors of the 1918 influenza epidemic whose blood still contained antibodies that 'fitted' the 1918 flu, but these will not have been produced at the maximum rate for nearly 100 years. To do so has a metabolic cost and would not be advantageous to the body either. The levels decline over time unless the signal is received to produce them again. This graph illustrates it better than I could explain. It is somewhat confused by the presence of some immunoglobulins who can 'work' in more subtle ways and find utility against more than one pathogen. Repeated infection by the same pathogen results in a far faster and more drastic response.

Image 1.png
 

manhill

Member
Thats not correct. Antibody half life differs from disease to disease. For tetanus its about 11 years, 50 years for chickenpox, for measles its 200 years. I myself had a blood test late last year that revealed I'd had Epstein Barr virus (aka glandular fever) at some point in my life, the doctor said there was no way of knowing when, as the antibodies stay in the blood for your entire life once you've had it.



For the common cold and the flu the half life of the antibodies is very short, weeks or months. Hence why we get reinfected with them constantly. Covid is a coronavirus which is the common cold family, and it seems the antibodies fade within months, like for colds. Thus we will all be capable of catching it repeatedly over our lives, unless a vaccine that can stimulate a far longer antibody half life can be found, which seems unlikely given actually having the virus is going to stimulate the immune system far more than a mild form in a vaccine.
U bin in Epstein's bar ??
Naughty boy!
 

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