Ivermectin , covid cure

[ollie989898]

He hasn't been cancelled from what I can see, but it's worth noting that he has form for unreliability. I'd want to know a little about a machinery dealer, or a livestock agent before making decisions about their wares, and this is no different.

'Unreliability' is putting it very politely.

 

[ollie989898]

@ollie989898 & @Cowabunga isn't the point with Ivermectin that it is a parasite killing drug ?

So I guess the reason it is used in Asia is to reduce parasitic load on populations that might suffer from Covid. Hence increasing likelihood of survival. Asian populations do like to eat raw fish for example.

I have no idea if UK populations suffer from worm parasites. It would be interesting to know after 50+ years whether we humans are likely to have such parasites.

The most likely source of UK infection would be from salad or early years infection whilst playing outside or interactions with dogs/cats.

It is a drug that is useful for parasites, yes. It is a widely used and well understood drug and we know how it works. It has been used for many many years and is available over the counter in many countries where such diseases are endemic.

It's anti-viral activity was demonstrated in laboratory research, in vitro, that is. Many other drugs demonstrate the same effect.

I have not yet seen any trials indicating its utility for covid-19 unfortunately.

 

[Crofter64]

He hasn't been cancelled from what I can see, but it's worth noting that he has form for unreliability. I'd want to know a little about a machinery dealer, or a livestock agent before making decisions about their wares, and this is no different.

Well,I’ve been following him for several years. My sister discovered him when she had bad cancer 13 years ago. She followed his recomendations( along with coventional treatment), bought his supplements and did very well. He offers free alternative advice , and during Covid became one of the few dissenting voices out there. He then became a platform for anyone who has another opinion, usually extremely qualified individuals who have been silenced by the mainstream. I don’t see anything wrong with someone selling supplements and using the profits to offer people free alternative information. The health food stores in Montreal all carry a free alternative medicine magazine.
He has been persecuted of late, chased to work by media who waited outside his house and has had a smear campaign against him.
CUI BONO?

 

[Crofter64]

Lockdowns are horrible! I don't blame anyone for feeling fed up to the back teeth with a continued lockdown.

I think the article is dated June last year.. ~ 4th June 2021.

Yes, that’s why I posted it. I took it out of context. It says,’ aren’t things rosy and great, we’ve beaten this virus’, but things actually aren’t. I’ve created a disconnect that , if you hadn’t done the simple research, would be confusing. This is the world we live in.
Just think: this thread of farmers has generated over 1500 posts on the question of whether Ivermectin or other drugs work on Covid. Why not let the science tell us directly? They certainly do know, but they aren’t telling. Doctor Robert Malone, interviewed by Joe Rogan ( and presented on Dr. Mercola‘s website) knows and says so. He also knows an awful lot about the behind the scenes stuff, but you won’t see him interviewed anywhere else. So live in darkness and dig around for the light or just ask someone who knows.

 

[Crofter64]

Better than the vaccine then?

No idea. The point was that taking it for several weeks did no harm. He will be 70 this year, teaches dance therapy ( don’t ask) ,used to be a star hockey player and lost his spleen in a game- he’s pretty fit though anyhow.

 

[Crofter64]

Where was the evidence that the vaccines actually worked until it was proven that they didn’t work anything like as well as expected, didn’t last as long and had far more serious adverse events than first thought? The evidence is often not in big trials but comes from experience during use, which is where the evidence for Ivermectin’s efficacy, or not, comes from. Not from big official trials, of which there has only been one, very recently completed and designed to fail. Nobody in the pharmacological industry wants a hint of it succeeding for reasons that have been illustrated many many times. They will not trial it, will cast doubt on its safety and demonise it in every way possible. This reached a crescendo a few months ago with a coordinated media storm that was demonstrably full of blatant lies, such as that US hospitals were full of overdosed Ivermectin patients and that some were shedding their guts. This was from a doctor that had not worked at a hospital for some time and which hospital authorities denied absolutely, stating categorically that they had not had a single such patient or even one with any side effect whatsoever. Not a single Ivermectin-related patient.
Not even the chap in the video YOU provided, probably without watching it, because you never do according to yourself, cast the slightest doubt on its safety. He did cast doubt on its efficacy though, but from some equally theoretical computer generated studies of a similar kind that others postulate as to how it actually works.

Experience on the ground in India, South America, Africa and now Japan seems to indicate that it does work. At the very least we can say that it does no harm and costs next to bugger-all. Those that think it is an alternative to vaccination and social distancing are the fools. I’m sure that both Pfizer and Merck will emphasise that their new products are an adjunct to vaccines for early intervention, not alternatives. That is where the Oxford trial went wrong, likely not by accident. I can bet you a fiver that no such ‘mistake’ will be done when it comes to these two novel new patented products. If the Oxford trial had been conducted appropriately and came up with the same result, fair enough. But everyone with an ounce of sense knew it wasn’t being conducted appropriately and I said so as soon as it was announced and described and am sticking to that view. It’s most unfortunate because it only persuades people like you, who just cannot think outside the box and look at the bigger picture.

The real problem with Ivermectin is , as you say, that it is cheap and readily available. There is nothing to be earned from distributing it . Medicine is a business that must return a profit on investment.

 

[Cowabunga]

@ollie989898 & @Cowabunga isn't the point with Ivermectin that it is a parasite killing drug ?

So I guess the reason it is used in Asia is to reduce parasitic load on populations that might suffer from Covid. Hence increasing likelihood of survival. Asian populations do like to eat raw fish for example.

I have no idea if UK populations suffer from worm parasites. It would be interesting to know after 50+ years whether we humans are likely to have such parasites.

The most likely source of UK infection would be from salad or early years infection whilst playing outside or interactions with dogs/cats.

Many drugs are multipurpose. Aspirin, for instance, is both a pain killer and a blood thinner that is also used as a first line treatment for heart attacks.
Anthelmintics in particular have a long history of being re-purposed. Thiabendazole is one of the oldest and probably the best established multipurpose anthelmintic that is now more often used as a human-destined fresh food preservative. Others in the same family are used and others show promise as chemotherapy agents.

Yes of course worms are an issue in the human population. Threadworms are a particular issue in the UK and the compulsory worming of farm dogs in the red tractor farm assurance scheme is specifically to help prevent humans being infected with worms and particularly the rather nasty hydatid disease.

 

[wanton dwarf]

Yes of course worms are an issue in the human population. Threadworms are a particular issue in the UK and the compulsory worming of farm dogs in the red tractor farm assurance scheme is specifically to help prevent humans being infected with worms and particularly the rather nasty hydatid disease.

It would be interesting to know if anyone has tested people who previously show no signs of worm infection with something like Invermectin and analysed the results - ie dead parasites in excreta including the mouth/nose.

 

[Crofter64]

From today’s free article from Dr. Mercola. Does anyone find any of this offensive?

Early Treatment Options​

While the overall risk of COVID-19 has been grossly exaggerated, early treatment is key, both for preventing severe infection and preventing “long-haul COVID.” Here are a few suggestions:
• Oral-nasal decontamination — The virus, especially the Delta variant, replicates rapidly in the nasal cavity and mouth for three to five days before spreading to the rest of the body, so you want to strike where it’s most likely to be found right from the start.
Research23 has demonstrated that irrigating your nasal passages with 2.5 milliliters of 10% povidone-iodine (an antimicrobial) and standard saline, twice a day, is an effective remedy.
Another option that was slightly less effective was using a mixture of saline with half a teaspoon of sodium bicarbonate (an alkalizer). You can also gargle with these to kill viruses in your mouth and throat. When done routinely, it can be a very effective preventive strategy. You can find printable treatment guides on TruthForHealth.org.
• Nebulized peroxide — A similar strategy is to use nebulized hydrogen peroxide, diluted with saline to a 0.1% solution. Both hydrogen peroxide and saline24,25 have antiviral effects. You can view my previous videos on this on BitChute.
In a May 10, 2021, Orthomolecular Medicine press release,26 Dr. Thomas E. Levy — board-certified in internal medicine and cardiology — discussed the use of this treatment for COVID-19 specifically. Levy has in fact written an entire book on peroxide nebulization called “Rapid Virus Recovery,” which you can download for free from MedFox Publishing.
• Vitamin D optimization — Research has shown having a vitamin D level above 50 ng/mL brings the risk of COVID mortality down to near-zero.27
• Other key nutraceuticals — Vitamin C, zinc, quercetin and NAC all have scientific backing.
• Key drugs — For acute infection, ivermectin, hydroxychloroquine or monoclonal antibodies can be used. While monoclonal antibodies and hydroxychloroquine must be used early on in the disease process, ivermectin has been shown to be effective in all stages of the infection.
Doxycycline or azithromycin are typically added as well, to address any secondary bacterial infection, as well as inhaled budesonide (a steroid). Oral steroids are used on and after the fifth day for pulmonary weakness and aspirin or NAC can be added to reduce the risk of clotting.
Full-strength aspirin is also typically recommended, but I believe lumbrokinase and serrapeptase may be a better, at least safer, alternative, as they help break down and prevent blood clots naturally.

 

[Cowabunga]

It would be interesting to know if anyone has tested people who previously show no signs of worm infection with something like Invermectin and analysed the results - ie dead parasites in excreta including the mouth/nose.

Ivermectin is selective, of course, and is not effective for flukes and, significantly, tapeworms. It is an extraordinarily safe drug and it has been reported that up until 2010, out of 25 million doses given to humans in Tanzania alone, only two very minor side effects were ever reported.

 

[Cowabunga]

It is a drug that is useful for parasites, yes. It is a widely used and well understood drug and we know how it works. It has been used for many many years and is available over the counter in many countries where such diseases are endemic.

It's anti-viral activity was demonstrated in laboratory research, in vitro, that is. Many other drugs demonstrate the same effect.

I have not yet seen any trials indicating its utility for covid-19 unfortunately.

We have only relatively recently, very recently, learnt how we think it works as an anthelmintic and it is not how many still think it works. It doesn’t actually kill the worm but chemically stops certain functions of the worm working so that white blood cells can attack and do the killing.
There is much speculation as to how effective it is as an anti-viral but the latest theory is that it does work by being a 3 CL Protease inhibitor, similar to the new Pfizer drug although it is likely that the Pfizer ‘Paxlovid' product [actually a combination of two drugs, one being to prolong the effectiveness of the other] will be more efficacious. How much more efficacious? No pharmaceutical company wishes to make that information public, and indeed they do not want to know.

 

[ollie989898]

We have only relatively recently, very recently, learnt how we think it works as an anthelmintic and it is not how many still think it works. It doesn’t actually kill the worm but chemically stops certain functions of the worm working so that white blood cells can attack and do the killing.
There is much speculation as to how effective it is as an anti-viral but the latest theory is that it does work by being a 3 CL Protease inhibitor, similar to the new Pfizer drug although it is likely that the Pfizer ‘Paxlovid' product [actually a combination of two drugs, one being to prolong the effectiveness of the other] will be more efficacious. How much more efficacious? No pharmaceutical company wishes to make that information public, and indeed they do not want to know.

It's nothing like the new Pfizer drug.

Ivermectin paralyses parasites, messes up their chloride ion channels. If they are paralysed, they will eventually be flushed out of the body and voided.

 

[Cowabunga]

It's nothing like the new Pfizer drug.

Ivermectin paralyses parasites, messes up their chloride ion channels. If they are paralysed, they will eventually be flushed out of the body and voided.

Maybe the Pfizer drug will turn out to be an equally efficacious anthelmintic. We don’t yet know.
What people guessed about how Ivermectin worked, up until very recently, has turned out to be mistaken. Are you actually denying that Ivermectin is an effective 3-CL Protease inhibitor? On what evidence?

 

[Bogweevil]

From today’s free article from Dr. Mercola. Does anyone find any of this offensive?

Early Treatment Options​

While the overall risk of COVID-19 has been grossly exaggerated, early treatment is key, both for preventing severe infection and preventing “long-haul COVID.” Here are a few suggestions:
• Oral-nasal decontamination — The virus, especially the Delta variant, replicates rapidly in the nasal cavity and mouth for three to five days before spreading to the rest of the body, so you want to strike where it’s most likely to be found right from the start.
Research23 has demonstrated that irrigating your nasal passages with 2.5 milliliters of 10% povidone-iodine (an antimicrobial) and standard saline, twice a day, is an effective remedy.
Another option that was slightly less effective was using a mixture of saline with half a teaspoon of sodium bicarbonate (an alkalizer). You can also gargle with these to kill viruses in your mouth and throat. When done routinely, it can be a very effective preventive strategy. You can find printable treatment guides on TruthForHealth.org.
• Nebulized peroxide — A similar strategy is to use nebulized hydrogen peroxide, diluted with saline to a 0.1% solution. Both hydrogen peroxide and saline24,25 have antiviral effects. You can view my previous videos on this on BitChute.
In a May 10, 2021, Orthomolecular Medicine press release,26 Dr. Thomas E. Levy — board-certified in internal medicine and cardiology — discussed the use of this treatment for COVID-19 specifically. Levy has in fact written an entire book on peroxide nebulization called “Rapid Virus Recovery,” which you can download for free from MedFox Publishing.
• Vitamin D optimization — Research has shown having a vitamin D level above 50 ng/mL brings the risk of COVID mortality down to near-zero.27
• Other key nutraceuticals — Vitamin C, zinc, quercetin and NAC all have scientific backing.
• Key drugs — For acute infection, ivermectin, hydroxychloroquine or monoclonal antibodies can be used. While monoclonal antibodies and hydroxychloroquine must be used early on in the disease process, ivermectin has been shown to be effective in all stages of the infection.
Doxycycline or azithromycin are typically added as well, to address any secondary bacterial infection, as well as inhaled budesonide (a steroid). Oral steroids are used on and after the fifth day for pulmonary weakness and aspirin or NAC can be added to reduce the risk of clotting.
Full-strength aspirin is also typically recommended, but I believe lumbrokinase and serrapeptase may be a better, at least safer, alternative, as they help break down and prevent blood clots naturally.

Quack, quack, quack

 

[Cowabunga]

From the summary of https://www.nature.com/articles/s42003-020-01577-x.


Interestingly, one of the OTD, ivermectin was able to inhibit more than 85% (almost completely) of 3CLpro activity in our in vitro enzymatic assay with an IC50 value of 21 µM. These findings suggest the potential of ivermectin to inhibit the SARS-CoV-2 replication. In support of this, a recent finding suggested that ivermectin (5 µM) inhibited the replication of live SARS-CoV-2 isolated from Australia (VIo1/2020) in Vero/hSLAM cells23. They found that >5000-fold viral counts were reduced in 48 hr in both culture supernatant (release of new virion: 93%) as well as inside the cells (unreleased and unassembled virion: 99.8%) when compared to DMSO treated infected cells. Interestingly, this study reported the IC50 value of ivermectin as 2.5 µM23, whereas, we observed an IC50 value of 21 µM (10-fold increase). The variability in the IC50 values reported could be attributed towards the differences in the assay conditions such as the use of live virus vs enzymatic assay with purified 3CLpro protein. Further, preclinical studies need to be established to validate the in vivo inhibitory activity and IC50 values of ivermectin.

Ivermectin is known to be effective against many positive-sense, single stranded RNA viruses such as Zika, Dengue, Yellow fever, West nile, Venezuelan equine encephalitis, Chikungunya, Semliki forest, Sindbis, Rorcine Reproductive and Respiratory Syndrome, and Human immunodeficiency-1 viruses38. The list of anti-viral effects of ivermectin against other RNA and DNA viruses were summarized in a recent review38. Earlier studies have demonstrated that the possible anti-viral mechanism of ivermectin was through the blockage of viral-protein transportation to the nucleus by inhibiting the interaction between viral protein and α/β1 importin heterodimer, a known transporter of viral proteins to the nucleus especially for RNA viruses19,20,21,22,23. However, in this study, we have reported that ivermectin inhibits the enzymatic activity of SARS-CoV-2 3CLpro and thus may potentially inhibit the replication of RNA viruses including SARS-CoV-2. These studies suggest that ivermectin could be a potential drug candidate to inhibit the SARS-CoV-2 replication and the proposed anti-viral mechanism of ivermectin presented in Fig. 8 and in vivo efficacy of ivermectin towards COVID-19 is currently been evaluated in clinical trials (ClinicalTrials.gov Identifier: NCT04438850).

 

[ollie989898]

From the summary of https://www.nature.com/articles/s42003-020-01577-x.


Interestingly, one of the OTD, ivermectin was able to inhibit more than 85% (almost completely) of 3CLpro activity in our in vitro enzymatic assay with an IC50 value of 21 µM. These findings suggest the potential of ivermectin to inhibit the SARS-CoV-2 replication. In support of this, a recent finding suggested that ivermectin (5 µM) inhibited the replication of live SARS-CoV-2 isolated from Australia (VIo1/2020) in Vero/hSLAM cells23. They found that >5000-fold viral counts were reduced in 48 hr in both culture supernatant (release of new virion: 93%) as well as inside the cells (unreleased and unassembled virion: 99.8%) when compared to DMSO treated infected cells. Interestingly, this study reported the IC50 value of ivermectin as 2.5 µM23, whereas, we observed an IC50 value of 21 µM (10-fold increase). The variability in the IC50 values reported could be attributed towards the differences in the assay conditions such as the use of live virus vs enzymatic assay with purified 3CLpro protein. Further, preclinical studies need to be established to validate the in vivo inhibitory activity and IC50 values of ivermectin.

Ivermectin is known to be effective against many positive-sense, single stranded RNA viruses such as Zika, Dengue, Yellow fever, West nile, Venezuelan equine encephalitis, Chikungunya, Semliki forest, Sindbis, Rorcine Reproductive and Respiratory Syndrome, and Human immunodeficiency-1 viruses38. The list of anti-viral effects of ivermectin against other RNA and DNA viruses were summarized in a recent review38. Earlier studies have demonstrated that the possible anti-viral mechanism of ivermectin was through the blockage of viral-protein transportation to the nucleus by inhibiting the interaction between viral protein and α/β1 importin heterodimer, a known transporter of viral proteins to the nucleus especially for RNA viruses19,20,21,22,23. However, in this study, we have reported that ivermectin inhibits the enzymatic activity of SARS-CoV-2 3CLpro and thus may potentially inhibit the replication of RNA viruses including SARS-CoV-2. These studies suggest that ivermectin could be a potential drug candidate to inhibit the SARS-CoV-2 replication and the proposed anti-viral mechanism of ivermectin presented in Fig. 8 and in vivo efficacy of ivermectin towards COVID-19 is currently been evaluated in clinical trials (ClinicalTrials.gov Identifier: NCT04438850).

God, not this again.

Look, a myriad of existing molecules will demonstrate the same effects on viruses in vitro and in silico. I've already mentioned/acknowledged this emphatically multiple times. Can we move it on a bit?

If you care to trawl the web, there are people explaining this in great detail. I seem to remember coming across a youtube video someone made on precisely this topic but I may be wrong.

 

[ollie989898]

From today’s free article from Dr. Mercola. Does anyone find any of this offensive?

Early Treatment Options​

While the overall risk of COVID-19 has been grossly exaggerated, early treatment is key, both for preventing severe infection and preventing “long-haul COVID.” Here are a few suggestions:
• Oral-nasal decontamination — The virus, especially the Delta variant, replicates rapidly in the nasal cavity and mouth for three to five days before spreading to the rest of the body, so you want to strike where it’s most likely to be found right from the start.
Research23 has demonstrated that irrigating your nasal passages with 2.5 milliliters of 10% povidone-iodine (an antimicrobial) and standard saline, twice a day, is an effective remedy.
Another option that was slightly less effective was using a mixture of saline with half a teaspoon of sodium bicarbonate (an alkalizer). You can also gargle with these to kill viruses in your mouth and throat. When done routinely, it can be a very effective preventive strategy. You can find printable treatment guides on TruthForHealth.org.
• Nebulized peroxide — A similar strategy is to use nebulized hydrogen peroxide, diluted with saline to a 0.1% solution. Both hydrogen peroxide and saline24,25 have antiviral effects. You can view my previous videos on this on BitChute.
In a May 10, 2021, Orthomolecular Medicine press release,26 Dr. Thomas E. Levy — board-certified in internal medicine and cardiology — discussed the use of this treatment for COVID-19 specifically. Levy has in fact written an entire book on peroxide nebulization called “Rapid Virus Recovery,” which you can download for free from MedFox Publishing.
• Vitamin D optimization — Research has shown having a vitamin D level above 50 ng/mL brings the risk of COVID mortality down to near-zero.27
• Other key nutraceuticals — Vitamin C, zinc, quercetin and NAC all have scientific backing.
• Key drugs — For acute infection, ivermectin, hydroxychloroquine or monoclonal antibodies can be used. While monoclonal antibodies and hydroxychloroquine must be used early on in the disease process, ivermectin has been shown to be effective in all stages of the infection.
Doxycycline or azithromycin are typically added as well, to address any secondary bacterial infection, as well as inhaled budesonide (a steroid). Oral steroids are used on and after the fifth day for pulmonary weakness and aspirin or NAC can be added to reduce the risk of clotting.
Full-strength aspirin is also typically recommended, but I believe lumbrokinase and serrapeptase may be a better, at least safer, alternative, as they help break down and prevent blood clots naturally.

You're at least 6 months too late with this. The stuff mentioned here has been debunked or chucked out of trials multiple times now.

I strongly recommend you do background reading on Dr Mercola and the other guy as well.

PS

No, Joe Rogan is not a source.

 

[Cowabunga]

God, not this again.

Look, a myriad of existing molecules will demonstrate the same effects on viruses in vitro and in silico. I've already mentioned/acknowledged this emphatically multiple times. Can we move it on a bit?

If you care to trawl the web, there are people explaining this in great detail. I seem to remember coming across a youtube video someone made on precisely this topic but I may be wrong.

Actually that is a precisely and specifically a comparison of the effect between different compounds including Ivermectin and it comes out very favourably in the comparison. You ignore it only because it is in direct conflict with your fixed point of view. I doubt that you have come across any YouTube video as you claim, if only because time and again you have claimed not to ever watch or give any measure of credibility to YouTube commentators or educators.

 

[ollie989898]

Actually that is a precisely and specifically a comparison of the effect between different compounds including Ivermectin and it comes out very favourably in the comparison. You ignore it only because it is in direct conflict with your fixed point of view. I doubt that you have come across any YouTube video as you claim, if only because time and again you have claimed not to ever watch or give any measure of credibility to YouTube commentators or educators.

I ignored it because I was already aware of it, I'm much more interested in the therapeutic use of the drug, unfortunately I am yet to see any trial data showing that it is worthwhile. I note also that a myriad of other compounds have also proved futile but the search goes on.

 

[primmiemoo]

Well,I’ve been following him for several years. My sister discovered him when she had bad cancer 13 years ago. She followed his recomendations( along with coventional treatment), bought his supplements and did very well. He offers free alternative advice , and during Covid became one of the few dissenting voices out there. He then became a platform for anyone who has another opinion, usually extremely qualified individuals who have been silenced by the mainstream. I don’t see anything wrong with someone selling supplements and using the profits to offer people free alternative information. The health food stores in Montreal all carry a free alternative medicine magazine.
He has been persecuted of late, chased to work by media who waited outside his house and has had a smear campaign against him.
CUI BONO?

Maybe he should be more careful about who he does business with, and what claims he makes about supplements? I've never heard of him before now, so don't know what his site was like prior to the pandemic. A quick search engine check shows he embroiled himself in the MMR scandal by steering parents away from vaccinating their children, and towards "alternatives" that, (un)surprisingly, he sold.

Consistently unreliable, to the point of dangerous, imv.