Ivermectin , covid cure

[ollie989898]

Perhaps you are more competent at taking a view on the possible mutagenic risk of Molnupiravir than you are for assessing the safety risk of Ivermectin? Would you also care to comment on the 'emergency license' application for Molnupiravir which has only had one small trial undertaken by its manufacturer and no safety trial whatsoever? Very like what happened with the vaccines which turned out to be far more risky than first claimed, resulting in many thousands of deaths and millions of adverse events worldwide, only, it seems to me, far more risky this time.

Can you direct me to a link where it demonstrates molnupiravir is mutagenic? Not that this would of course would actually preclude it from being used. Many chemotherapeutic agents are themselves recognised carcinogens.

 

[milkloss]

Can you direct me to a link where it demonstrates molnupiravir is mutagenic? Not that this would of course would actually preclude it from being used. Many chemotherapeutic agents are themselves recognised carcinogens.

I still had a Google tab open from the other week

Molnupiravir is mutagenic for mammals too

www.bmj.com

 

[Cowabunga]

Can you direct me to a link where it demonstrates molnupiravir is mutagenic? Not that this would of course would actually preclude it from being used. Many chemotherapeutic agents are themselves recognised carcinogens.

They have not tested it. For anything in any comprehensive way. Let alone having independent large scale peer-reviewed positive trials for efficacy or safety for which you insist absolutely for other products. You are so insistent on tests for selected medicines yet you make excuses and deflect from the fact that a product that may, due to its mode of action on RNA/DNA be mutagenic, which is very different to ''carcinogenic'' which I never mentioned, is held to a completely lower standard by you, as indeed were the vaccines from the start; the safety and efficacy data for which has only been gathered during experience of mass use and which are both rather disappointing.

I'm now convinced that you have huge comprehension issues among others.

 

[Cowabunga]

The very latest positive information from Japan. A must-see...

 

[ollie989898]

They have not tested it. For anything in any comprehensive way. Let alone having independent large scale peer-reviewed positive trials for efficacy or safety for which you insist absolutely for other products. You are so insistent on tests for selected medicines yet you make excuses and deflect from the fact that a product that may, due to its mode of action on RNA/DNA be mutagenic, which is very different to ''carcinogenic'' which I never mentioned, is held to a completely lower standard by you, as indeed were the vaccines from the start; the safety and efficacy data for which has only been gathered during experience of mass use and which are both rather disappointing.

I'm now convinced that you have huge comprehension issues among others.

Are you sure it has not been tested? Molnupiravir, like many of the similar antivirals, has been around for a little while. I would have expected trials to test it's efficacy and safety to have been done to be honest.

Yes, some drugs are known to be carginogenic in their own right. Mutagenic is very similar as concepts go hence why I mentioned it and also to highlight the fact that, yes, the fact something apparently has deleterious affects to the person being treated may not preclude it from being used (back to the whole harm vs benefit thing). I don't know why you are becoming so instantly hostile here but I have noted this is a common habit of yours.

I don't know what studies have been done for molnupiravir, I know it is one of the antivirals but it is one amongst many others and I haven't bothered to read much about it. I always believed an existing antiviral agent would prove useful for covid-19 and that it would be just be a matter of time.

I also don't know what you are eluding to where you are mentioning the safety or efficacy of vaccines, either. I suspect the trials they have had conducted on them were rather more reliable than in the trials yet cited for ivermectin, however. As I have said before, mRNA vaccines are not new, they too have been around for a while and like any other vaccine they will have been trialled to demonstrate their efficacy and safety before they were used. I don't have any details in my memory as it stopped being news so long ago but a very brief google comes up with this, I note cited 5000 times as well where the authors discuss the safety and efficacy of the Pfizer vaccine.

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine | NEJM

Original Article from The New England Journal of Medicine — Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

www.nejm.org

You will note that they did not rely on meta-analysis for this. The trial mentioned recruited over 40,000 participants: not just the cursory 400 or so needed to really generate statistically meaningful results. This number of course becomes rather elusive when we look to the ivermectin trials yet mentioned on this thread.

I still don't quite understand your agenda. Are you vociferously anti-vaccine or what, exactly? Please do explain your point of view. I have no particular dog in this hunt. I said right at the outset that I didn't believe ivermectin would work. I found the idea that a virtually everyday drug invented nigh on 60 years ago or whatever it is would turn out to be the cure for a novel pandemic involving coronaviruses really would be the stuff of dreams. I recognised early on that this virus would be far from simple to combat for the same reasons that colds and flu have not yet been beaten despite plenty of billions being spent trying.

 

[Cowabunga]

Are you sure it has not been tested? Molnupiravir, like many of the similar antivirals, has been around for a little while. I would have expected trials to test it's efficacy and safety to have been done to be honest.

Yes, some drugs are known to be carginogenic in their own right. Mutagenic is very similar as concepts go hence why I mentioned it and also to highlight the fact that, yes, the fact something apparently has deleterious affects to the person being treated may not preclude it from being used (back to the whole harm vs benefit thing). I don't know why you are becoming so instantly hostile here but I have noted this is a common habit of yours.

I don't know what studies have been done for molnupiravir, I know it is one of the antivirals but it is one amongst many others and I haven't bothered to read much about it. I always believed an existing antiviral agent would prove useful for covid-19 and that it would be just be a matter of time.

I also don't know what you are eluding to where you are mentioning the safety or efficacy of vaccines, either. I suspect the trials they have had conducted on them were rather more reliable than in the trials yet cited for ivermectin, however. As I have said before, mRNA vaccines are not new, they too have been around for a while and like any other vaccine they will have been trialled to demonstrate their efficacy and safety before they were used. I don't have any details in my memory as it stopped being news so long ago but a very brief google comes up with this, I note cited 5000 times as well where the authors discuss the safety and efficacy of the Pfizer vaccine.

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine | NEJM

Original Article from The New England Journal of Medicine — Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

www.nejm.org

You will note that they did not rely on meta-analysis for this. The trial mentioned recruited over 40,000 participants: not just the cursory 400 or so needed to really generate statistically meaningful results. This number of course becomes rather elusive when we look to the ivermectin trials yet mentioned on this thread.

I still don't quite understand your agenda. Are you vociferously anti-vaccine or what, exactly? Please do explain your point of view. I have no particular dog in this hunt. I said right at the outset that I didn't believe ivermectin would work. I found the idea that a virtually everyday drug invented nigh on 60 years ago or whatever it is would turn out to be the cure for a novel pandemic involving coronaviruses really would be the stuff of dreams. I recognised early on that this virus would be far from simple to combat for the same reasons that colds and flu have not yet been beaten despite plenty of billions being spent trying.

You are deluded. There were no extensive trials on the safety of the vaccines. You know full well that they were only granted an emergency licence to cut through and short proper trials and you also know that serious and not so serious adverse events and even deaths are far higher than ever expected and efficacy far less so in many respects.
With every post you make your ignorance becomes more obvious.

 

[ollie989898]

You are deluded. There were no extensive trials on the safety of the vaccines. You know full well that they were only granted an emergency licence to cut through and short proper trials and you also know that serious and not so serious adverse events and even deaths are far higher than ever expected and efficacy far less so in many respects.
With every post you make your ignorance becomes more obvious.

Did you not even bother to read the link I posted?

 

[Highland Mule]

Did you not even bother to read the link I posted?

Not sure he can read. Have you not got it as a Youtube video?

 

[ollie989898]

Stolen from twitter. Don't know how accurate the numbers are. But a nice visual format.

 

[ollie989898]

As I said, in some parts of Europe they have big numbers of cases and low vaccination rates.

 

[ollie989898]

Big pharmaceutical conspiracy...

undefined | The Financial Express

thefinancialexpress.com.bd

Bangladesh’s pharmaceutical companies have begun marketing generic versions of Merck's COVID-19 antiviral drug molnupiravir, the first of its kind, upon approval from regulators.

Beximco began the sales on Tuesday after getting the emergency production and marketing authorisation on Monday, said Maj Gen Md Mahbubur Rahman, director-general of the Directorate General of Drug Administration.

Eskayef and Square Pharmaceuticals, who received nods for the production and marketing of the drug, will begin marketing the pill within the next week, reports bdnews24.com.


Incepta, General Pharma, Beacon Pharma, Renata and three other companies have also received the production go-ahead from the DGDA.

Beximco Pharma is supplying the drug with the brand name Emorivir at Tk 70 per capsule. Eskayef has priced its pills, Monuvir, at Tk 50 each.

A patient needs to take eight 200 mg capsules daily - four at a time, two times a day - for five days following a doctor’s prescription to treat mild to moderate infections. Trial research has suggested that the pill is likely to be most effective when taken during the early stages of infection.

“We think the drug will help eliminate coronavirus from the country,” said Mahbubur, the chief of DGDA.

Bangladeshi pharmaceutical companies were able to swiftly bring in the medicine due to having rights to “copyright exemption” on some drugs as a “developing country”, Mahbubur said.

On Oct 27, Merck granted a royalty-free licence for its promising COVID-19 pill to the United Nations-backed nonprofit Medicines Patent Pool, an organisation that works to make medical treatment and technologies globally accessible.

The deal has allowed companies in 105 countries, mostly in Africa and Asia and including Bangladesh, to sublicence the formulation for the antiviral pill and begin making it.

 

[Trutti]

Big pharmaceutical conspiracy...

undefined | The Financial Express

thefinancialexpress.com.bd

Bangladesh’s pharmaceutical companies have begun marketing generic versions of Merck's COVID-19 antiviral drug molnupiravir, the first of its kind, upon approval from regulators.

Beximco began the sales on Tuesday after getting the emergency production and marketing authorisation on Monday, said Maj Gen Md Mahbubur Rahman, director-general of the Directorate General of Drug Administration.

Eskayef and Square Pharmaceuticals, who received nods for the production and marketing of the drug, will begin marketing the pill within the next week, reports bdnews24.com.


Incepta, General Pharma, Beacon Pharma, Renata and three other companies have also received the production go-ahead from the DGDA.

Beximco Pharma is supplying the drug with the brand name Emorivir at Tk 70 per capsule. Eskayef has priced its pills, Monuvir, at Tk 50 each.

A patient needs to take eight 200 mg capsules daily - four at a time, two times a day - for five days following a doctor’s prescription to treat mild to moderate infections. Trial research has suggested that the pill is likely to be most effective when taken during the early stages of infection.

“We think the drug will help eliminate coronavirus from the country,” said Mahbubur, the chief of DGDA.

Bangladeshi pharmaceutical companies were able to swiftly bring in the medicine due to having rights to “copyright exemption” on some drugs as a “developing country”, Mahbubur said.

On Oct 27, Merck granted a royalty-free licence for its promising COVID-19 pill to the United Nations-backed nonprofit Medicines Patent Pool, an organisation that works to make medical treatment and technologies globally accessible.

The deal has allowed companies in 105 countries, mostly in Africa and Asia and including Bangladesh, to sublicence the formulation for the antiviral pill and begin making it.

Pfizer are doing the same …not insisting on patent protection and releasing it to generic drug manufacturers. Kind of destroys the “big” money argument. Vaccines are ”at cost” also.

 

[ollie989898]

Pfizer are doing the same …not insisting on patent protection and releasing it to generic drug manufacturers. Kind of destroys the “big” money argument. Vaccines are ”at cost” also.

There may have been a poster mentioning this many pages earlier on this thread. Maybe? Can't remember...

 

[Cowabunga]

So generic versions will be available very cheaply in Western economies will they? Of course not! Don't be silly.

Have you seen how Covid cases have dropped off a very steep cliff in Japan within 10 days of allowing over the counter sales of Ivermectin country wide? If you have, you are studiously ignoring it, as are the mainstream Western media.

 

[neilo]

I wish you guys would go easy on the ivermec. Wynnstays haven't had any in stock for 3 weeks now, and had to buy some online instead.

 

[ollie989898]

Show me the evidence.

 

[Cowabunga]

Show me the evidence.

Already done. You have, as usual, chosen not to see it.

 

[ollie989898]

Already done. You have, as usual, chosen not to see it.

Where? I can't tell you how keen I am to read a journal article demonstrating the efficacy of ivermectin.

ITECH just demonstrated it doesn't work.

Effect of Ivermectin on Time to Resolution of Symptoms Among Adults With Mild COVID-19: A Randomized Clinical Trial - PubMed

ClinicalTrials.gov Identifier: NCT04405843.

pubmed.ncbi.nlm.nih.gov

...Conclusion and relevance: Among adults with mild COVID-19, a 5-day course of ivermectin, compared with placebo, did not significantly improve the time to resolution of symptoms. The findings do not support the use of ivermectin for treatment of mild COVID-19...

 

[tullah]

Where? I can't tell you how keen I am to read a journal article demonstrating the efficacy of ivermectin.

ITECH just demonstrated it doesn't work.

Effect of Ivermectin on Time to Resolution of Symptoms Among Adults With Mild COVID-19: A Randomized Clinical Trial - PubMed

ClinicalTrials.gov Identifier: NCT04405843.

pubmed.ncbi.nlm.nih.gov

...Conclusion and relevance: Among adults with mild COVID-19, a 5-day course of ivermectin, compared with placebo, did not significantly improve the time to resolution of symptoms. The findings do not support the use of ivermectin for treatment of mild COVID-19...

Ivermectin is best taken when symptoms first appear. I suspect the trials took place after covid had got ahold so the results were not as clear cut.

 

[Cowabunga]

Where? I can't tell you how keen I am to read a journal article demonstrating the efficacy of ivermectin.

Japan! I don't believe in coincidences.
The date where the yellow pointer is situated is when Ivermectin was first allowed to be prescribed by all Japanese doctors without prescription and the population were otherwise allowed to buy it with no restriction or prescription.