Updated SCOPS advice on Cydectin 2%

[Macsky]

Updated advice on moxidectin 2% a result of constructive discussion between SCOPS and leading animal health company | SCOPS News

Updated advice on moxidectin 2% a result of constructive discussion between SCOPS and leading animal health company, news from SCOPS, the sustainable control of parasites in sheep.

www.scops.org.uk

Id be interested to know who has resistance to moxidectin now and what were the methods of use that led to this? Is resistance with the long acting active in this product inevitable?

 

[Nithsdale]

Can't answer your first part


But with a persistent/long acting anthelmintic used regularly within any flock, it is putting heavy selection pressure on resistant worms by killing all those susceptible to the drug. So yes if used regularly, resistance is inevitable and will occur quicker than other 'short acting' anthelmintics

 

[Macsky]

Can't answer your first part


But with a persistent/long acting anthelmintic used regularly within any flock, it is putting heavy selection pressure on resistant worms by killing all those susceptible to the drug. So yes if used regularly, resistance is inevitable and will occur quicker than other 'short acting' anthelmintics

How regular is regular? Once a year/once a season?

 

[Bury the Trash]

As well as Poor administration technique, not knowing accurate weight of animal, ie underdosing , nozzle or needle just shoved in and hope for the best along with poorly restrained livestock .

 

[Joe]

I was a private talk recently by a animal health expert and he finished the talk by stating you should never use Moxidectin products. He claimed its method of selective targeting of worms was a sure path to resistance, found it interesting as had never heard it previously.

 

[Nithsdale]

How regular is regular? Once a year/once a season?

The 2% LA is persistent for 111 days, which means it stays in the ewes system killing worms for 111 days (more than 3months!!). That is the equivalent of dosing your ewes with a standard oral drench, every day for 111 consecutive days. Remember most oral drenches kill everything in the ewe on that day, but have 0 persistency...

Honestly, the product should be taken off the shelves IMO.

Definitely should never be used routinely, and as SCOPS now say it shouldn't even be used once s year.

 

[neilo]

The 2% LA is persistent for 111 days, which means it stays in the ewes system killing worms for 111 days (more than 3months!!). That is the equivalent of dosing your ewes with a standard oral drench, every day for 111 consecutive days. Remember most oral drenches kill everything in the ewe on that day, but have 0 persistency...

Honestly, the product should be taken off the shelves IMO.

Definitely should never be used routinely, and as SCOPS now say it shouldn't even be used once s year.

It only kills some species of worms for a long period, other species are far less cover. It stands to reason that there is a tail off of ai in the bloodstream over time, so it’s actually like drenching with the full dose of an oral product, then again and again with lower & lower doses over several months.
With the species for which it gives less cover, you are actually giving them continuous sub-lethal doses for the rest of the 3 months.

The only place i’ve Used it recently has been for a lambing dose for ewe lambs, which run with the (undrenched) single ewes right through to weaning. And as part of quarantine protocol for anything coming in, on my vet’s advice.

 

[sean m]

It only kills some species of worms for a long period, other species are far less cover. It stands to reason that there is a tail off of ai in the bloodstream over time, so it’s actually like drenching with the full dose of an oral product, then again and again with lower & lower doses over several months.
With the species for which it gives less cover, you are actually giving them continuous sub-lethal doses for the rest of the 3 months.

The only place i’ve Used it recently has been for a lambing dose for ewe lambs, which run with the (undrenched) single ewes right through to weaning. And as part of quarantine protocol for anything coming in, on my vet’s advice.

this^ its the tail off period that causes the problem as i understand it

 

[Nithsdale]

It only kills some species of worms for a long period, other species are far less cover. It stands to reason that there is a tail off of ai in the bloodstream over time, so it’s actually like drenching with the full dose of an oral product, then again and again with lower & lower doses over several months.
With the species for which it gives less cover, you are actually giving them continuous sub-lethal doses for the rest of the 3 months.

The only place i’ve Used it recently has been for a lambing dose for ewe lambs, which run with the (undrenched) single ewes right through to weaning. And as part of quarantine protocol for anything coming in, on my vet’s advice.

Same difference. I just put it in simple terms

Long exposure breeds resistance which is not good for the industry

 

[Macsky]

Is there much difference between moxidectin and doramectin? if you’re resistant to cydectin, will you resistant to dectomax?