Levafas diamond

[1982]

Dipped ewes on the 27th January.Was thinking of dosing the ewes tomorrow with Levafas diamond.
It says on box not to use product if ewes have been treated with organophosphate either 2 weeks before or 2 weeks after intended treatment.
Can anyone explain why?
Tia

 

[Nithsdale]

Safety of Anthelmintics - Pharmacology - MSD Veterinary Manual

Learn about the veterinary topic of Safety of Anthelmintics. Find specific details on this topic and related topics from the MSD Vet Manual.

www.msdvetmanual.com

"...The safety index (SI) is not as wide for levamisole (SI = 4–6), nor for most of the chemicals active against liver flukes (SI = 3–6). Mammalian toxicity with levamisole is seen more often than with benzimidazoles, although toxic signs are unusual unless the normal therapeutic dosage is exceeded. Levamisole toxicity in the host animal is largely an extension of its antiparasitic effect, ie, cholinergic-type signs of salivation, muscle tremors, ataxia, urination, defecation, and collapse. In fatal levamisole poisoning, the immediate cause of death is asphyxia due to respiratory failure. Atropine sulfate can alleviate such signs. Levamisole may cause some inflammation at the site of SC injection, but usually this is transient. Toxicity increases if other anticholinergic drugs (eg, organophosphates) are given at the same time.

Because of their low absorption from the gut, tetrahydropyrimidines have a high safety margin. Adverse effects (vomiting in dogs and cats) are rare. Toxicity increases when other cholinergic drugs (eg, levamisole, organophosphates) are used simultaneously.

The margin of safety for organophosphates is generally less than that of the benzimidazoles, and strict attention to dosage is necessary. Generally, their toxicity is additive; thus, concurrent use of other cholinesterase-inhibiting drugs should be avoided. Atropine and 2-PAM are used as antidotes to organophosphate toxicity (also see Organophosphate Toxicosis in Animals). Organophosphates also can be hazardous to people..."

 

[Greythundercloudys]

I was told not to use diamond at this time of year . Superverm or flukiver straight. Diamond in the autumn.

 

[neilo]

I was told not to use diamond at this time of year . Superverm or flukiver straight. Diamond in the autumn.

No. Levafas Diamond will only kill mature fluke (& rumen fluke).

In the Autumn, you would want a product which kills immature fluke, which is only Triclabendazole products such as Fasinex.

 

[Nithsdale]

 

[hally]

Don’t do any lambs with LD on decent grass as it skitters the life out of them……learned the hard way

 

[Anymulewilldo]

No. Levafas Diamond will only kill mature fluke (& rumen fluke).

In the Autumn, you would want a product which kills immature fluke, which is only Triclabendazole products such as Fasinex.

Or endofluke for the peasants amongst us…