essex man
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Mmm....had just read that and thought it worth posting ...beat me to it!Very interesting article on Original Antigenic Sin here:
More on Original Antigenic Sin and the Folly of Our Universal Vaccination Campaign
A deeper look at a decisive limitation of our adaptive immune systems.eugyppius.substack.com
The basic premise being that when the human immune system first meets a new virus, the immune response that is created will then dominate the bodies response for the rest of that person's life. So if you get infected with flu aged 15 with flu variant A, your body will always try to use antibodies to Variant A first for the rest of your life, even as you catch Variants B, C and D over time. Its very difficult to change the bodies response, to stimulate new immune responses with vaccines etc, if you have already had an infection prior to vaccination. The response is always dominated by the first variant encountered.
Thus what we are doing with the vaccines is setting in stone a person's immune response to covid, to the spike protein from Variant Alpha, assuming they have not been infected naturally first of course. Thus its no surprise that when new variants arrive, such as Delta, immune response in vaccinated people is not as good - it is set up for the Alpha spike protein, and always will be, and can't cope as well with Delta. So over time, as covid mutates further and further away from Alpha, the vaccine efficiency will drop each time. And it will be no good giving boosters based on new variants, because the immune system doesn't learn very well once its had that initial infection. This is why flu vaccines don't work that well - by the time we get a flu vaccine we've most likely already had flu once in our lives, and that infection has set our immune response for good.
This is why vaccinating children is so dangerous, for them. Instead of them catching a disease which holds them virtually no danger whatsoever, and gaining a full immune response to the latest virus variant, they would be getting an immune response to just one part of an old variant that has virtually disappeared. An immune response that will then hamstring them for the rest of their lives as they struggle to cope with repeated infections from new variants over time. And as they have the longest to live out of all of us, they are going to face the most new variants.